Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin againstCandidaspecies are reduced by farnesol

Susceptibility pattern of Candida albicans isolated from Iranian patients to antifungal agents

Background and Purpose: Candidiasis is a major fungal infection, and Candida albicans is the major cause of infections in humans. The Clinical and Laboratory Standards Institute (CLSI) developed new breakpoints for antifungal agents against C. albicans. In this multi-center study, we aimed to determine the drug susceptibility profile of C. albicans, isolated from Iranian population according...

Effect of Fluconazole, Amphotericin B and Caspofungin against Candida albicans

Comparison of caspofungin and amphotericin B for invasive candidiasis.

BACKGROUND Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive candidiasis. METHODS We enrolled patients who had clinical evidence of infection and a positive culture for candida species from blood or another site. Patients were str...

Determination of minimum inhibitory concentrations.

Minimum inhibitory concentrations (MICs) are defined as the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation, and minimum bactericidal concentrations (MBCs) as the lowest concentration of antimicrobial that will prevent the growth of an organism after subculture on to antibiotic-free media. MICs are used by diagnostic la...

Caspofungin was as effective as amphotericin B for invasive candidiasis.

P a t i e n t s 239 patients > 18 years of age who had ≥ 1 positive candida culture from blood or another sterile site in the past 4 days, and ≥ 1 clinical sign of infection in the past 2 days (fever, hypothermia, or hypotension) or signs of inflammation at a candida-infected site. Exclusion criteria included suspected endocarditis, osteomyelitis, or meningitis; and receipt of antifungal therap...